Akali from League of Legends. Yep I am incredibly fucked. There literally no way to really escape her either. If she was hunting me down for something other than killing me I wouldn't be fucked but since killing is literally her job and she was hunting me down because of her job then I would definitely be fucked. And not just normal fucked either.
She isn't the only main character in that game. There's like 100 characters that are/could be mains I guess. But she was just last one I used in that game.